Protective effects of trifluoperazine, a calmodulin antagonist
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چکیده
منابع مشابه
Trifluoperazine, a calmodulin antagonist, inhibits muscle cell fusion
We investigated the effect of trifluoperazine (TFP), a calmodulin antagonist, on the fusion of chick skeletal myoblasts in culture. TFP was found to inhibit myoblast fusion. This effect occurs at concentrations that have been reported to inhibit Ca2+-calmodulin in vitro, and is reversed upon removal of TFP. In addition, other calmodulin antagonists, including chlorpromazine, N-(6-aminohexyl)-5-...
متن کاملProtective effects of calmodulin antagonists (trifluoperazine and W-7) on hypothermic ischemic rat hearts.
The cardioprotective effect of calmodulin antagonists, trifluoperazine (TFP) and N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) was examined on the isolated rat heart exposed to hypothermic and ischemic conditions by measuring distribution of lysosomal enzymes in myocardial cells, and leakage of creatine kinase (CK) during reperfusion and postischemic recovery in myocardial systolic ...
متن کاملEffects of Trifluoperazine on Calcium Binding by Calmodulin
Microcalorimetric titrations of calmodulin with Ca" and trifluoperazine (TFP) at various molar ratios have been carried out at 25 "C and at pH 7.0. Ca2+ binding to calmodulin produces heat ( A H ) in the presence of TFP, while heat is absorbed in the absence of TFP. The total heat produced by Ca2+ binding to all four sites is increased at increasing TFP-to-calmodulin ratios, attaining a plateau...
متن کاملEffects of trifluoperazine on calcium binding by calmodulin. A microcalorimetric study.
Microcalorimetric titrations of calmodulin with Ca2+ and trifluoperazine (TFP) at various molar ratios have been carried out at 25 degrees C and at pH 7.0. Ca2+ binding to calmodulin produces heat (-delta H) in the presence of TFP, while heat is absorbed in the absence of TFP. The total heat produced by Ca2+ binding to all four sites is increased at increasing TFP-to-calmodulin ratios, attainin...
متن کاملEffects of trifluoperazine and pimozide
The possible involvement of calmodulin in insulin release was evaluated by studying the effects on intact islets of trifluoperazine and pimozide, two antipsychotic agents known to bind strongly to calmodulin in cell-free systems. Trifluoperazine (10-100#UM) produced a doseand time-dependent inhibition of the two phases of glucose-stimulated insulin release. The effect was not reversible by simp...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1990
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.102.9-10_1033